Documentation Centre

March 27, 2013

Pathophysiology of adipose tissue, insulin resistance and inflammation

By The International Chair on Cardiometabolic Risk [17:10 min.] [266MB]

Drs. Després, Tchernof and Marette discuss several issues related to adipose tissue morphology and metabolism as well as processes associated with inflammation.Dr. Tchernof begins the discussion by explaining his clinical research program where through a collaborative effort with surgeons, he could have access to several types of human adipose tissue such as intra-abdominal (visceral) adipose tissue, allowing his team to explore differences in the biology of various body fat compartments.The conversation is followed by a description of a comprehensive research program which explores the drivers of cardiovascular disease risk in patients with type 2 diabetes. This program is led by Dr. André Marette as Principal Investigator. Molecular, genetic and clinical aspects of diabetes complications represent different cores of this large research program.Finally, Dr. Marette discusses some nutritional factors which could potentially modulate adipose tissue physiology and processes involved in inflammation and insulin resistance.

Key Words
Adipose Tissue, Inflammation, Insulin Resistance