The Concept of CMR
Slides, videos and moreEvaluating CMR
Assessing CVD Risk: Traditional Approaches
Others
- 1Key Points (1 page)
- 2Estimating CHD Risk (1 page)
- 3The SCORE Project (2 pages)
- 4The UKPDS Risk Engine (2 pages)
- 5The Italian CUORE Project (2 pages)
- 6References (1 page)
The UKPDS Risk Engine
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For CHD estimation, a fully parametric model combining hazards ratio and absolute events rates in a single equation was used to estimate events rates and survival probabilities. Health planners can use the UKPDS model to estimate resource use, perform power calculations in clinical trials, and estimate effectiveness and cost-effectiveness early in drug development cycles.
In comparison with previous models that do not include any measure of glycemia, an important feature of the UKPDS model is the inclusion of HBA1c as a continuous CHD risk factor. A direct causal relationship between glycemia measured by HBA1c, and CHD has not yet been proven (30), but it is important to acknowledge that a predictive relationship does exist (31, 32). The UKPDS prediction model also includes some important CHD risk factors such as blood pressure (33) and total cholesterol/HDL cholesterol ratio (34). The UKPDS risk engine is therefore a good model for estimating CHD risk for the primary prevention of CHD in type 2 diabetic patients.
For more information, please visit the UKPDS website at http://www.dtu.ox.ac.uk/index.php?maindoc=/ukpds/.
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