The Concept of CMR
Slides, videos and moreEvaluating CMR
Metabolic Syndrome and Type 2 Diabetes/CVD Risk
Comparison of Screening Tools
- 1Key Points (1 page)
- 2How Are Screening Tools Different? (1 page)
- 3The Insulin Resistance Atherosclerosis Study (1 page)
- 4The Aerobics Center Longitudinal Study (1 page)
- 5The San Antonio Heart Study (1 page)
- 6The Hoorn Study (2 pages)
- 7The DECODE Study (1 page)
- 8The Prospective Epidemiological Study of Myocardial Infarction (1 page)
- 9The Strong Heart Study (1 page)
- 10Additional Evidence (2 pages)
- 11References (1 page)
The Hoorn Study
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The Hoorn Study is a population-based cohort study of diabetes that included 615 asymptomatic men and 749 asymptomatic women 50 to 75 years of age (4). The study investigated the incidence of fatal and nonfatal CVD associated with metabolic syndrome clinical criteria proposed by NCEP-ATP III, WHO, EGIR, and a modified version of AACE. The results of the Hoorn Study were published at the same time as the proposed IDF criteria, and therefore the authors could not compare IDF criteria to the others. In men, metabolic syndrome prevalence was 19%, 32%, 19%, and 41%, respectively, when NCEP-ATP III, WHO, EGIR, and AACE criteria were used. In women, the respective prevalence of the metabolic syndrome was 26%, 26%, 17%, and 35%. The Hoorn Study was the first study to compare metabolic syndrome prevalence between criteria using Cohen’s agreement test (κ). In men, the best coefficient of concordance was found between WHO and EGIR criteria (both criteria relying mostly on insulin resistance) with κ=0.66 (95% CI, 0.59-0.72). The poorest coefficient of concordance was found between WHO and NCEP-ATP III criteria with κ=0.37 (95% CI, 0.29-0.45). In women, the strongest coefficient of concordance was between NCEP-ATP III and AACE criteria with κ=0.78 (95% CI, 0.73-0.82), while the poorest coefficient of concordance was between EGIR and AACE criteria with κ=0.36 (95% CI, 0.29-0.43).
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