Usefulness of Hypertriglyceridemic Waist

Hypertriglyceridemic Waist and Coronary Risk

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The combination of a large waist circumference with elevated triglyceride concentrations increased CVD risk among individuals with either normal or abnormal glucose levels (hazard ratio: 1.82; 95% CI: 1.27-2.62 and 2.68; 95% CI: 1.89-3.81, respectively). Another prospective study tested the hypothesis that hypertriglyceridemic waist, as a covariate of metabolic syndrome features, predicted premature CAD among patients with glucose intolerance or type 2 diabetes (28). The sample included 1,990 men and women, including 592 patients with impaired glucose tolerance or type 2 diabetes. Survival models revealed that among patients with impaired glucose tolerance or type 2 diabetes, those with hypertriglyceridemic waist experienced their first CAD symptoms 5 years earlier than those without this phenotype. This elevated and earlier risk of CAD was statistically significant (hazard ratio 2.0; 95% CI: 1.2-3.7, p = 0.02). Thus, although the relationship between glucose levels and CVD risk is well established, these findings suggest that the presence/absence of hypertriglyceridemic waist could be useful to clinicians in refining assessment of CVD risk due to a dysglycemic or prediabetic state. The presence of abdominal obesity and hypertriglyceridemia should therefore be a warning sign for physicians.

Reference

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28. St-Pierre J, Lemieux I, Perron P, et al. Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus. Am J Cardiol 2007; 99: 369-73.

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