Managing CMR

Managing Cardiometabolic Risk in Abdominally Obese Patients

Physical Activity and Exercise

Exercise and Thrombosis

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Thrombosis (the formation of a blood clot in an intact blood vessel) is a key precursor to stroke, myocardial infarction, and other overt symptoms of blood flow obstruction throughout the circulatory system (99). While physical inactivity is a major risk factor for thrombosis, an acute bout of strenuous exercise has been reported to cause a prothrombotic state and predispose sedentary and at-risk individuals to cardiovascular events (99, 100). A number of investigations and reviews (99-101) have examined the relationship between acute and chronic exercise. Their findings as well as various hemostatic and fibrinolytic factors that contribute to thrombosis are summarized below.


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99. Lee KW and Lip GY. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Arch Intern Med 2003; 163: 2368-92.
100. Koenig W and Ernst E. Exercise and thrombosis. Coron Artery Dis 2000; 11: 123-7.
101. El-Sayed MS, Sale C, Jones PG, et al. Blood hemostasis in exercise and training. Med Sci Sports Exerc 2000; 32: 918-25.