The Concept of CMR
Slides, videos and moreManaging CMR
Managing Cardiometabolic Risk in Abdominally Obese Patients
Physical Activity and Exercise
- 1Key Points (1 page)
- 2Exercise and Cardiometabolic Risk (2 pages)
- 3Exercise and Abdominal Obesity (3 pages)
- 4Exercise and Insulin Resistance (5 pages)
- 5Exercise and Atherogenic Dyslipidemia (4 pages)
- 6Exercise and Elevated Blood Pressure (3 pages)
- 7Exercise and Thrombosis (3 pages)
- 8Exercise and Systemic Inflammation (3 pages)
- 9References (1 page)
Exercise and Thrombosis
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Conversely, cross-sectional studies (106, 107) consistently document the antithrombotic effect of chronic exercise, which lowers fibrinogen levels (and related coaguability) and increases fibrinolytic capacity (also seen after acute exercise). Numerous exercise intervention studies have also documented enhanced fibrinolytic capacity after regular exercise training, as indicated by an increase in tissue plasminogen activator (a fibrolytic stimulator) and a decrease in plasminogen activator inhibitor type 1 (PAI-1) (108-110). Regular, moderate-intensity endurance exercise also appears to suppress platelet adhesiveness and aggregation, both at rest and following acute intense exercise (110-112). However, these thrombotic factors quickly revert to pretraining values upon cessation of chronic exercise training (111, 112), suggesting that regular exercise must be maintained for its antithrombotic effects to last.
Overall, it seems that while regular, moderate-intensity exercise can reduce the risk of cardiovascular events by improving an individual’s hemostatic and fibrinolytic profile, intense acute exercise may trigger myocardial infarction, especially in at-risk individuals, by inducing a hypercoaguable state (99, 100). These findings account for the apparent paradox between chronic and acute exercise and thrombosis (113) and provide further support for regular, moderate-intensity exercise as a means to prevent cardiovascular events.
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