The Concept of CMR
Slides, videos and moreThe Concept of CMR
Intra-abdominal Adipose Tissue: the Culprit?
Liver Fat
- 1Key Points (1 page)
- 2Liver Fat: a Marker of Ectopic Fat Deposition (1 page)
- 3Epidemiology (1 page)
- 4Liver Fat and Metabolic Disease (1 page)
- 5Pathogenesis (3 pages)
- 6Measuring Liver Fat (2 pages)
- 7References (1 page)
Key Points
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- Non-alcoholic fatty liver disease is a common cause of chronic liver disease and is closely associated with a range of cardiometabolic risk factors as well as diabetes and mortality risk.
- It is unknown how liver fat develops but a number of plausible mechanisms have been proposed, including ‘spillover’ of excess energy from adipose tissue, adiponectin deficiency, a high fat diet, and/or overactivation of the endocannabinoid system.
- Increased liver fat storage is related to hepatic insulin resistance and increased synthesis and secretion of atherogenic lipoproteins.
- The gold standard method for quantifying liver fat is liver biopsy. However, imaging techniques such as magnetic resonance spectroscopy (MRS) and computed tomography (CT) are safe and reliable alternatives.
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