The Concept of CMR

Intra-abdominal Adipose Tissue: the Culprit?

Influence of Menopause

Key Points

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  • Abdominal (visceral) adiposity increases with the onset of menopause.
  • Abdominal tissue redistribution with menopause appears to be independent of age and total body fat and could be related to a relative deficit in estrogens.
  • Menopause has a negative impact on plasma lipoprotein-lipid levels, which may increase CVD risk.
  • HTR in post-menopausal women helps protect against intra-abdominal fat accumulation. However, prospective studies that have assessed “hard” CVD endpoints have failed to confirm HRT’s benefits. Current evidence does not support the use of HRT to reduce menopause-related CVD risk.