The Concept of CMR
Slides, videos and moreThe Concept of CMR
Intra-abdominal Adipose Tissue: the Culprit?
Pro-thrombotic State
- 1Key Points (1 page)
- 2Fat Distribution and Pro-thrombotic State (1 page)
- 3Hypofibrinolysis (1 page)
- 4Platelet Hyperactivity (1 page)
- 5Hypercoagulability (1 page)
- 6Obesity and Inflammation (1 page)
- 7Oxidative Stress (1 page)
- 8Endothelial Dysfunction (1 page)
- 9References (1 page)
Key Points
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- Obese, insulin-resistant subjects and type 2 diabetic patients often have a pro-thrombotic state.
- Atherothrombotic complications of the metabolic syndrome are partly due to a dysregulation of hemostasis. This induces a pro-thrombotic state that includes endothelial activation, platelet hyperactivity, hypercoagulability, and hypofibrinolysis.
- Hypofibrinolysis because of elevated PAI-1 levels is a core feature of the metabolic syndrome.
- Weight loss improves all pro-thrombotic factors, indicating that obesity is a modifiable risk factor for thrombosis.
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